Biofermentation product of Bacillus subtilis (BS) and Streptomyces saraceticus (SS) were applied to control rice leaf blight caused byXanthomonas campestris pv. oryzae. Both biocontrol agent were spray on rice leaf in different dilute concentrations. In the treatment of BS (300X) had provided significant suppression of rice leaf blight disease but no significant effect on product enhance. On the result of different biocontrol agent spray timing BS100X sprayed 5 days before pathogen inoculation had significantly control effect. On the relationship of bioagent sprayed and rice agriculture characters appeared influence, sprayed bioagent could enhance rice spiracles number, but no effect on the other characters. From our result, use biocontrol agent could control rice leaf blight disease and have no any negative influence on its agronomic characters.