研究彙報第九十期 ， Page 41- 50，出版時間： 2006- 3， 詳細內容

山防風水萃物對小鼠體內免疫調節之研究

作者： 郭肇凱、顏國欽、許輔、張隆仁

　　 試驗以 BALB/c 小鼠體內模式探討山 防風 水萃冷凍乾燥樣本所產生之免疫反應，結果體內非特異性免疫調節活性試驗發現，餵食山 防風 水萃冷凍乾燥樣本之小鼠單核球百分吞噬率可以顯著 ( P <0.05 ) 高於餵食對照組；體內 Ovalbumin (OVA) 特異性免疫調節活性試驗發現，餵食山 防風 水萃冷凍乾燥樣本之小鼠脾細胞，相較於餵食對照組會顯著 ( P <0.05 ) 增加 OVA 特異性之脾細胞增生率，而且其血清相較於餵食對照組會產生顯著 ( P <0.05 ) OVA 特異性之 IgG 生成，有助於體液防禦對抗侵害性之特異抗原。

關鍵字： 山防風、免疫調節、吞噬作用、細胞增生、免疫球蛋白。

　　 The objective of this study was to evaluate the immunomodulatory effects of Echin ops grijsii extract in an in vivo experiments using BALB/c mice. The non-specific immunomodulatory experiments showed that administration of E. grijsii extract significantly ( P <0.05 ) increased the phagocytosis percentage of monocytes. Besides, the OVA-specific immunomodulatory experiments showed that administration of E. grijsii extract not only significantly ( P <0.05 ) enhanced the OVA-specific cell proliferation of mouse splenocytes but also stimulated OVA-specific IgG production significantly ( P <0.05 ). It is speculated that the consumption of E. grijsii is useful for defending the invading specific antigens.

keywords: Echinops grijsii, immunomodulatory function, phagocytosis, cell proliferation, immunoglobulin.